Preparation and in-vitro evaluation of poly [N-vinyl-2-pyrrolidone-polyethylene glycol diacrylate]-chitosan interpolymeric pH-responsive hydrogels for oral drug …
KL Shantha, DRK Harding - International journal of pharmaceutics, 2000 - Elsevier
Biocompatible and biodegradable pH-responsive hydrogels based on N-vinyl pyrrolidone
(NVP), polyethylene glycol diacrylate (PAC) and chitosan were prepared for controlled drug
delivery. These interpolymeric hydrogels were synthesized by a free radical polymerization
technique using azobisisobutyronitrile (AIBN) as initiator and N, N′-
methylenebisacrylamide (BIS) as crosslinker. These hydrogels were subjected to
equilibrium swelling studies in enzyme-free simulated gastric and intestinal fluids (SGF and …
(NVP), polyethylene glycol diacrylate (PAC) and chitosan were prepared for controlled drug
delivery. These interpolymeric hydrogels were synthesized by a free radical polymerization
technique using azobisisobutyronitrile (AIBN) as initiator and N, N′-
methylenebisacrylamide (BIS) as crosslinker. These hydrogels were subjected to
equilibrium swelling studies in enzyme-free simulated gastric and intestinal fluids (SGF and …
